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Development of mannosylated liposomes for bioadhesive oral drug delivery via M cells of Peyer's patches Mannosylated liposomes for oral drug delivery Pongthep Pukanud et al.

Issued Date

2009-11-09

Resource Type

Article

ISSN

15210464
10717544

DOI

10.1080/10717540902989738

Other identifier(s)

2-s2.0-70349319399

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Drug Delivery. Vol.16, No.5 (2009), 289-294

Suggested Citation

Pongthep Pukanud, Penchom Peungvicha, Narong Sarisuta Development of mannosylated liposomes for bioadhesive oral drug delivery via M cells of Peyer's patches Mannosylated liposomes for oral drug delivery Pongthep Pukanud et al.. Drug Delivery. Vol.16, No.5 (2009), 289-294. doi:10.1080/10717540902989738 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28313

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Title

Development of mannosylated liposomes for bioadhesive oral drug delivery via M cells of Peyer's patches Mannosylated liposomes for oral drug delivery Pongthep Pukanud et al.

Author(s)

Pongthep Pukanud
 Penchom Peungvicha
 Narong Sarisuta

Other Contributor(s)

Mahidol University

Abstract

The aim of this study was to develop mannosylated liposomes as bioadhesive carriers for oral drug delivery. Two kinds of acyclovir (ACV)entrapped mannosylated liposomes, i.e. ManN-ACV-lip and PAM-ACV-lip, were prepared by the use of mannosamine HCl (ManN) and p-aminophenyl-α-D-mannopyranoside (PAM), respectively. The mean sizes, drug entrapment efficiency, and loading capacity values of all liposomal formulations were in the ranges of 233371nm, 8295%, and 4247%, respectively. The mean size of PAM-ACV-lip was significantly smaller than those of conventional ACV liposomes and ManN-ACV-lip due to the more conical packing parameter of mannose-conjugated phospholipid. The mannosylating group grafted into bilayer membrane resulted in a decrease in drug entrapment, owing to competitive binding. The in vitro drug absorptions through everted sacs of mice ileum of both mannosylated ACV liposomes were significantly higher than those of conventional ACV liposomes or suspension. © 2009 Informa UK Ltd.

Keyword(s)

Pharmacology, Toxicology and Pharmaceutics

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https://repository.li.mahidol.ac.th/handle/20.500.14594/28313

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