Publication: Response to JE vaccine among HIV-infected children, Bangkok, Thailand
Issued Date
1998-09-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0032149340
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.29, No.3 (1998), 443-450
Suggested Citation
Suntharee Rojanasuphot, Nathan Shaffer, Tawee Chotpitayasunondh, Supaporn Phumiamorn, Philip Mock, Sanay Chearskul, Narit Waranawat, Prayoon Yuentrakul, Timothy D. Mastro, Theodore F. Tsai Response to JE vaccine among HIV-infected children, Bangkok, Thailand. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.29, No.3 (1998), 443-450. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18498
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Title
Response to JE vaccine among HIV-infected children, Bangkok, Thailand
Abstract
Since 1990, Japanese encephalitis (JE) vaccine has been part of EPI in northern Thailand, where there is a high prevalence of JE and HIV infection. To evaluate the immunogenicity and safety of JE vaccine among HIV-infected children, we conducted a retrospective study of HIV-infected and uninfected children who received 2 doses of JE vaccine at 12 months of age. Pre- and post-immunization plasma specimens were tested by plaque reduction neutralization for antibody levels to JE and dengue(1-4) viruses; titers of ≥10 were considered positive. Excluding 5 children with preimmunization antibodies, 5 of 14 (36%) HIV-infected children and 18 of 27 (67%) uninfected children had positive JE antibody titers after immunization [odds ratio (OR) 0.3, p=0.06]; 31% absolute difference [95% confidence interval (CI) 0-61.7%). The geometric mean titer of HIV-infected children with positive titers was lower than that of control children (15.1 vs, 23.8; p=0.17). No significant vaccine-associated adverse events were noted. We conclude that primary antibody response to JE vaccine was low among HIV-infected children and was approximately half of that seen among uninfected children. In endemic areas, HIV-infected children are likely to be at risk of acquiring JE despite routine immunization with 2 doses.