Publication: Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression.
Accepted Date
2014-03-11
Issued Date
2014-03-17
Copyright Date
2014
Resource Type
Language
eng
ISSN
1475-2875 (electronic)
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Viriyavejakul P, Khachonsaksumet V, Punsawad C. Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression. Malar J. 2014 Mar 17;13:106.
Suggested Citation
Parnpen Viriyavejakul, พรรณเพ็ญ วิริยเวชกุล, Vasant Khachonsaksumet, วสันต์ ขจรศักดิ์สุเมธ, Chuchard Punsawad, ชูชาติ พันธ์สวัสดิ์ Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression.. Viriyavejakul P, Khachonsaksumet V, Punsawad C. Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression. Malar J. 2014 Mar 17;13:106.. doi:10.1186/1475-2875-13-106. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/765
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Title
Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression.
Corresponding Author(s)
Abstract
BACKGROUND: Liver involvement in severe Plasmodium falciparum infection is
commonly a significant cause of morbidity and mortality among humans. The
clinical presentation of jaundice often reflects a certain degree of liver
damage. This study investigated the liver pathology of severe P. falciparum
malaria as well as the regulation and occurrence of apoptosis in cellular
components of formalin-fixed, paraffin-embedded liver tissues.
METHODS: The liver tissues used in the study came from patients who died from P.
falciparum malaria with hyperbilirubinaemia (total bilirubin (TB)≥ 51.3 μmol/L or
3 mg/dl) (12 cases), P. falciparum malaria without hyperbilirubinaemia (TB<51.3
μmol/L) (10 cases); and patients who died due to accidents, whose liver histology
was normal (the control group) (10 cases). The histopathology of the liver tissue
was studied by routine histology method. Caspase-3 and nuclear factor kappa B
(NF-κB) p65 expressions were determined using immunohistochemistry.
RESULTS: The severity of liver histopathology, occurrence of apoptosis and NF-κB
p65 activation in P. falciparum malaria were associated with higher TB level.
Significant correlations were found between NF-κB p65 expression and apoptosis in
Kupffer cells and lymphocytes in the portal tracts.
CONCLUSIONS: Hyperplastic Kupffer cells and portal tract inflammation are two
main features found in the liver tissues of severe P. falciparum malaria cases.
In addition, NF-κB is associated with Kupffer cells and lymphocyte apoptosis in
severe P. falciparum malaria.