Publication:
Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients

Issued Date

2018-01-01

Resource Type

Article

ISSN

23147156
23148861

DOI

10.1155/2018/2780272

Other identifier(s)

2-s2.0-85042656504

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Mahidol University

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SCOPUS

Bibliographic Citation

Journal of Immunology Research. Vol.2018, (2018)

Suggested Citation

Chonlaphat Sukasem, Chonlawat Chaichan, Thapanat Nakkrut, Patompong Satapornpong, Kanoot Jaruthamsophon, Thawinee Jantararoungtong, Napatrupron Koomdee, Suthida Sririttha, Sadeep Medhasi, Sarawut Oo-Puthinan, Ticha Rerkpattanapipat, Jettanong Klaewsongkram, Pawinee Rerknimitr, Papapit Tuchinda, Leena Chularojanamontri, Napatra Tovanabutra, Apichaya Puangpetch, Wichai Aekplakorn Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients. Journal of Immunology Research. Vol.2018, (2018). doi:10.1155/2018/2780272 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46079

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Title

Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients

Author(s)

Chonlaphat Sukasem
 Chonlawat Chaichan
 Thapanat Nakkrut
 Patompong Satapornpong
 Kanoot Jaruthamsophon
 Thawinee Jantararoungtong
 Napatrupron Koomdee
 Suthida Sririttha
 Sadeep Medhasi
 Sarawut Oo-Puthinan
 Ticha Rerkpattanapipat
 Jettanong Klaewsongkram
 Pawinee Rerknimitr
 Papapit Tuchinda
 Leena Chularojanamontri
 Napatra Tovanabutra
 Apichaya Puangpetch
 Wichai Aekplakorn

Other Contributor(s)

Chulalongkorn University
 Faculty of Medicine, Prince of Songkia University
 Naresuan University
 Mae Fah Luang University
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Mahidol University
 Faculty of Medicine, Siriraj Hospital, Mahidol University
 Prasat Neurological Institute
 Chiang Mai University
 Thai Severe Cutaneous Adverse Drug Reaction (Thai-SCAR) Research Group

Abstract

© 2018 Chonlaphat Sukasem et al. The HLA-B∗15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of the present study was to carry out an analysis of the involvement of HLA-B alleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population. A case-control study was performed by genotyping the HLA-B alleles of Thai carbamazepine-induced hypersensitivity reaction patients (17 MPE, 16 SJS/TEN, and 5 DRESS) and 271 carbamazepine-tolerant controls. We also recruited 470 healthy Thai candidate subjects who had not taken carbamazepine. HLA-B∗15:02 showed a significant association with carbamazepine-induced MPE (P=0.0022, odds ratio (OR) (95% confidence interval [CI]) = 7.27 (2.04-25.97)) and carbamazepine-induced SJS/TEN (P=4.46×10-13; OR (95% CI) = 70.91(19.67-255.65)) when compared with carbamazepine-tolerant controls. Carbamazepine-induced SJS/TEN also showed an association with HLA-B∗15:21 allele (P=0.013; OR (95% CI) = 9.54 (1.61-56.57)) when compared with carbamazepine-tolerant controls. HLA-B∗58:01 allele was significantly related to carbamazepine-induced MPE (P=0.007; OR (95% CI) = 4.73 (1.53-14.66)) and DRESS (P=0.0315; OR (95% CI) = 7.55 (1.20-47.58)) when compared with carbamazepine-tolerant controls. These alleles may serve as markers to predict carbamazepine-induced cADRs in the Thai population.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/46079

Collections

Scopus 2018