Publication: A simple presurgical necrotizing enterocolitis-mortality scoring system
Issued Date
2006-12-01
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ISSN
14765543
07438346
07438346
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2-s2.0-33751355406
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Perinatology. Vol.26, No.12 (2006), 764-768
Suggested Citation
U. Kessler, A. Mungnirandr, M. Nelle, A. F. Nimmo, Z. Zachariou, S. Berger A simple presurgical necrotizing enterocolitis-mortality scoring system. Journal of Perinatology. Vol.26, No.12 (2006), 764-768. doi:10.1038/sj.jp.7211613 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23454
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Title
A simple presurgical necrotizing enterocolitis-mortality scoring system
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Abstract
Objective: To assess the relationship between early laboratory parameters, disease severity, type of management (surgical or conservative) and outcome in necrotizing enterocolitis (NEC). Study design: Retrospective collection and analysis of data from infants treated in a single tertiary care center (1980 to 2002). Data were collected on disease severity (Bell stage), birth weight (BW), gestational age (GA) and pre-intervention laboratory parameters (leukocyte and platelet counts, hemoglobin, lactate, C-reactive protein). Results: Data from 128 infants were sufficient for analysis. Factors significantly associated with survival were Bell stage (P<0.05), lactate (P<0.05), BW and GA (P<0.01, P<0.001, respectively). From receiver operating characteristics curves, the highest predictive value resulted from a score with 0 to 8 points combining BW, Bell stage, lactate and platelet count (P<0.001). At a cutoff level of 4.5 sensitivity and specificity for predicting survival were 0.71 and 0.72, respectively. Conclusion: Some single parameters were associated with poor outcome in NEC. Optimal risk stratification was achieved by combining several parameters in a score.