Publication: Dengue viremia and dengue seroprevalence in blood donors, bangkok, thailand
Issued Date
2021-03-25
Resource Type
ISSN
26975718
01251562
01251562
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2-s2.0-85119918065
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.52, No.2 (2021), 327-341
Suggested Citation
Aumnad Khongsup, Parichart Permpikul, Panisadee Avirutnan, Adisak Songjaeng, Nattaya Tangthawornchaikul, Tanapan Prommool, Nuntaya Punyadee, Dumrong Mairiang, Chunya Puttikhunt Dengue viremia and dengue seroprevalence in blood donors, bangkok, thailand. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.52, No.2 (2021), 327-341. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78346
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Title
Dengue viremia and dengue seroprevalence in blood donors, bangkok, thailand
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Abstract
Dengue virus (DENV) infection is a major public health problem worldwide. Dengue clinical manifestations may range from asymptomatic, to mild symptomatic, and to a life-threatening shock syndrome. In endemic countries including Thailand blood donations from asymptomatic dengue-infected persons pose a risk for DENV transmission. We investigated the prevalence of dengue viremia and dengue immunity among Thai blood donors (n = 400) from August 2015 to March 2016 using nested RT-PCR and anti-DENV IgM/IgG capture ELISA. Only one donor was positive for dengue virus serotype 2 (DENV2) viremia as revealed by RT-quantitative PCR and virus isolation. After a two-month follow up, the donor did not develop symptoms related to DENV infection and anti-DENV IgG and IgM levels remained just above and below cut-off values, respectively and were unchanged from the day of blood donation. In dengue serological studies, anti-DENV antibody ELISA was positive for IgG in 246 (61%) and both IgG and IgM in 24 (6%) of blood donors, respectively. In conclusion, the prevalence of detectable dengue (DENV2) viremia in blood donors in Bangkok was 0.25% but there still exists concern in dengue endemic regions of a finite risk of infection from blood transfusions. Further studies with a larger sample size will be required to evaluate the cost-benefit of an additional measure to detect dengue viremia in blood donations in Thailand.