Andrew J. Williams, Suda Chakthong, Diane Gray, Ron M. Lawrence, Timothy Gallagher 1,2-Cyclic sulfamidates as versatile precursors to thiomorpholines and piperazines. Organic Letters. Vol.5, No.6 (2003), 811-814. doi:10.1021/ol027418h Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20754
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1,2-Cyclic sulfamidates as versatile precursors to thiomorpholines and piperazines
(Matrix presented) 1,2-Cyclic sulfamidates undergo regiospecific nucleophilic displacement with either methyl thioglycolate or α-amino esters, followed by lactamization (thermal, base-mediated, or cyanide-catalyzed), to give thiomorpholin-3-ones and piperazin-2-ones.
