Publication: Hydrogen peroxide toxicity induces Ras signaling in human neuroblastoma SH-SY5Y cultured cells
Issued Date
2010-10-18
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ISSN
11107251
11107243
11107243
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2-s2.0-77957838992
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Biomedicine and Biotechnology. Vol.2010, (2010)
Suggested Citation
Banthit Chetsawang, Jirapa Chetsawang, Piyarat Govitrapong Hydrogen peroxide toxicity induces Ras signaling in human neuroblastoma SH-SY5Y cultured cells. Journal of Biomedicine and Biotechnology. Vol.2010, (2010). doi:10.1155/2010/803815 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28616
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Title
Hydrogen peroxide toxicity induces Ras signaling in human neuroblastoma SH-SY5Y cultured cells
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Abstract
It has been reported that overproduction of reactive oxygen species occurs after brain injury and mediates neuronal cells degeneration. In the present study, we examined the role of Ras signaling on hydrogen peroxide-induced neuronal cells degeneration in dopaminergic neuroblastoma SH-SY5Y cells. Hydrogen peroxide significantly reduced cell viability in SH-SY5Y cultured cells. An inhibitor of the enzyme that catalyzes the farnesylation of Ras proteins, FTI-277, and a competitive inhibitor of GTP-binding proteins, GDP-beta-S significantly decreased hydrogen peroxide-induced reduction in cell viability in SH-SY5Y cultured cells. The results of this study might indicate that a Ras-dependent signaling pathway plays a role in hydrogen peroxide-induced toxicity in neuronal cells. Copyright 2010 Jirapa Chetsawang et al.