Publication: Inhibition of oxidative stress through the induction of antioxidant enzymes of pigmented rice bran in HEK-293 cells
Issued Date
2017-01-01
Resource Type
ISSN
15559475
1934578X
1934578X
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2-s2.0-85026437790
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Mahidol University
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SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.12, No.7 (2017), 1107-1110
Suggested Citation
Ruksinee Khammanit, Pattamapan Lomarat, Natthinee Anantachoke, Vilasinee H. Sato, Malyn Ungsurungsie, Supachoke Mangmool Inhibition of oxidative stress through the induction of antioxidant enzymes of pigmented rice bran in HEK-293 cells. Natural Product Communications. Vol.12, No.7 (2017), 1107-1110. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41575
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Title
Inhibition of oxidative stress through the induction of antioxidant enzymes of pigmented rice bran in HEK-293 cells
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Abstract
The cellular antioxidant enzymes play an essential role on the protection of oxidative stress. Pigmented rice bran is the major sources of phytochemicals and elicits antioxidant property. However, the effects of pigmented rice bran on the upregulation of cellular antioxidant enzymes are incompletely understood. In this study, we demonstrated that treatment of HEK-293 cells with pigmented rice bran extracts (200 ìg/mL) from Red Hawm, Red Rose, Black Sukhothai-II, and Kum Doisaket strains significantly inhibited H2O2-induced intracellular ROS production. These pigmented rice bran extracts induced mRNA expression of glutathione peroxidase-1 (GPx-1), glutathione reductase and catalase. Additionally, treatment with these rice bran extract also increased protein expression of GPx-1 and catalase. Thus, these pigmented rice bran extracts exert the cellular antioxidant effects by decreasing ROS generation as well as increasing the production of antioxidant enzymes.