Publication: Artemisinin: Large community studies
Issued Date
1994-01-01
Resource Type
ISSN
18783503
00359203
00359203
Other identifier(s)
2-s2.0-0028277862
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.88, (1994), 45-46
Suggested Citation
FranÇis Nosten Artemisinin: Large community studies. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.88, (1994), 45-46. doi:10.1016/0035-9203(94)90472-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9590
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Artemisinin: Large community studies
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Abstract
Prospective randomized trials with oral artemisinin derivatives have been conducted in over 1000 patients to determine the optimum treatment of multi-drug resistant falciparum malaria on the Thai-Burmese border. These drugs have proved valuable in 3 settings, (i) Primary treatment of uncomplicated malaria in combination with mefloquine, when they accelerate the rate of recovery, eliminate the risk of dangerous early failures, and if given for 3 d or more improve overall cure rates; (ii) treatment of recrudescent infections, which otherwise have a high failure rate; and (iii)oral treatment of patients with high parasitaemias (≥4%) but no clinical evidence of severity (a group who would usually receive parenteral quinine). The parenteral formulation of artemether is absorbed if given rectally, and this may offer a practical alternative method of treating severe malaria in rural areas. © 1994 Oxford University Press.