Publication:
Directed deprotonation-transmetallation of 4-bromopyridine: Flexible routes to substituted pyridines

Issued Date

2002-05-20

Resource Type

Article

ISSN

09365214

Other identifier(s)

2-s2.0-0036250925

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Synlett. No.5 (2002), 808-810

Suggested Citation

Gunter Karig, Nopporn Thasana, Timothy Gallagher Directed deprotonation-transmetallation of 4-bromopyridine: Flexible routes to substituted pyridines. Synlett. No.5 (2002), 808-810. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20129

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Title

Directed deprotonation-transmetallation of 4-bromopyridine: Flexible routes to substituted pyridines

Author(s)

Gunter Karig
 Nopporn Thasana
 Timothy Gallagher

Other Contributor(s)

University of Bristol
 Chulabhorn Research Institute
 Mahidol University

Abstract

Halide-directed deprotonation and Li-Zn exchange of 4-bromopyridine 4 provides organozinc 6, which undergoes Pd-mediated coupling to give the 3-aryl-4-bromopyridines 7. Further substitution is achieved to provide the 3,4-disubstituted pyridines 8 and 9, and the 3,4,5-trisubstituted variants 10.

Keyword(s)

Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/20129

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Scopus 2001-2005