Publication: Provocation proven drug allergy in Thai children with adverse drug reactions
Issued Date
2016-03-01
Resource Type
ISSN
22288694
0125877X
0125877X
Other identifier(s)
2-s2.0-84962541017
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.34, No.1 (2016), 59-64
Suggested Citation
Somying Indradat, Jittima Veskitkul, Punchama Pacharn, Orathai Jirapongsananuruk, Nualanong Visitsunthorn Provocation proven drug allergy in Thai children with adverse drug reactions. Asian Pacific Journal of Allergy and Immunology. Vol.34, No.1 (2016), 59-64. doi:10.12932/AP0601.34.1.2016 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/40853
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Provocation proven drug allergy in Thai children with adverse drug reactions
Other Contributor(s)
Abstract
© 2016, Allergy and Immunology Society of Thailand. All rights reserved. Background: Adverse drug reactions (ADRs) are a common healthcare problem. The drug provocation test (DPT) is a gold standard for ADR diagnosis. Objectives: To evaluate a correlation between history of ADRs, skin prick test (SPT), intradermal test (ID) and DPT in Thai children. Methods: This was a retrospective review of 211 children under 16 years of age who had a history of ADRs and underwent DPT from January 2006 to December 2012. Results: Two hundred and thirty six (236) DPTs were performed in 211 children with a history of ADRs. The median age at which DPTs were performed was 4 years. Thirty-four children (14.4%) had positive DPT. The positive predictive value (PPV), negative predictive value (NPV), sensitivity, specificity, likelihood ratio (LR) + and LR- of SPT were 50, 85.7, 6.9, 98.8%, 5.8 and 0.9, respectively. The PPV, NPV, sensitivity, specificity, LR+ and LR- of ID were 33.3, 84.6, 20, 91.7%, 2.4 and 0.9, respectively. Different presentation of symptoms (maculopapular rashes, urticaria, angioedema and anaphylaxis) did not predict SPT, ID and DPT results. Positive human immunodeficiency virus (HIV), but not atopy, was a risk in the present scope of evaluation for drug allergy (odds ratio 11.44, 95% confidence interval 2.60-50.41). Conclusion: Drug allergy, denoted by positive DPT, was present in 14.4% of Thai children with a history of ADRs. Antibiotics were the most common cause of ADRs. Both SPT and ID had high NPV and specificity but did not predict DPT results. HIV positivity is a risk factor of drug allergy in Thai children.