Publication: Significant association between TNF-α (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand
Issued Date
2007-03-01
Resource Type
ISSN
13990039
00012815
00012815
Other identifier(s)
2-s2.0-34247881850
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Mahidol University
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SCOPUS
Bibliographic Citation
Tissue Antigens. Vol.69, No.3 (2007), 277-280
Suggested Citation
H. Hananantachai, J. Patarapotikul, J. Ohashi, I. Naka, S. Krudsood, S. Looareesuwan, K. Tokunaga Significant association between TNF-α (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand. Tissue Antigens. Vol.69, No.3 (2007), 277-280. doi:10.1111/j.1399-0039.2006.00756.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24240
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Title
Significant association between TNF-α (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand
Other Contributor(s)
Abstract
We examined a possible association of three single nucleotide polymorphisms (SNPs) of the tumor necrosis factor alpha (TNF) promoter -1031T>C (rs1799964), -863C>A (rs1800630), and -857C>T (rs1799724) with severe malaria in 466 adult patients having Plasmodium falciparum malaria in northwest Thailand. Four TNF promoter alleles comprising these three SNPs were detected in the studied population. The frequency of the TNF U04 allele designated -1031C, -863C, and -857C was found to be significantly greater in patients with cerebral malaria than in patients with mild malaria (12.6%, cerebral malaria vs 5.6%, mild malaria; odds ratio = 2.5; P = 0.002). The association of U04 with susceptibility to cerebral malaria was not caused by linkage disequilibrium with any specific HLA-B and -DRB1 alleles. © 2007 Blackwell Munksgaard.