Publication: Liver procollagen prolyl hydroxylase in Opisthorchis viverrini infected hamsters after praziquantel administration
Issued Date
1983-01-01
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ISSN
01666851
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2-s2.0-0021013142
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecular and Biochemical Parasitology. Vol.9, No.4 (1983), 289-295
Suggested Citation
Nongporn Hutadilok, Witaya Thamavit, E. Suchart Upatham, Pintip Ruenwongsa Liver procollagen prolyl hydroxylase in Opisthorchis viverrini infected hamsters after praziquantel administration. Molecular and Biochemical Parasitology. Vol.9, No.4 (1983), 289-295. doi:10.1016/0166-6851(83)90085-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30441
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Title
Liver procollagen prolyl hydroxylase in Opisthorchis viverrini infected hamsters after praziquantel administration
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Abstract
Infection of hamsters by the human liver fluke Opisthorchis viverrini elevated liver procollagen prolyl hydroxylase activity, reflecting increased collagen biosynthesis. The increase was proportional to the intensity of infection. However, the infected liver procollagen prolyl hydroxylase activity decreased after administration of praziquantel 300 mg kg-1body weight, and approached normal levels two weeks after treatment. In the infected hamsters, praziquantel, at a curative dose, caused a transient increase in serum aminotransferase levels and a small but persistent rise in serum alkaline phosphatase. The drug, however, did not cause changes in these enzyme activities in the uninfected hamsters. © 1983.