Publication:
Liver procollagen prolyl hydroxylase in Opisthorchis viverrini infected hamsters after praziquantel administration

1

Issued Date

1983-01-01

Resource Type

Article

ISSN

01666851

DOI

10.1016/0166-6851(83)90085-3

Other identifier(s)

2-s2.0-0021013142

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Molecular and Biochemical Parasitology. Vol.9, No.4 (1983), 289-295

Suggested Citation

Nongporn Hutadilok, Witaya Thamavit, E. Suchart Upatham, Pintip Ruenwongsa Liver procollagen prolyl hydroxylase in Opisthorchis viverrini infected hamsters after praziquantel administration. Molecular and Biochemical Parasitology. Vol.9, No.4 (1983), 289-295. doi:10.1016/0166-6851(83)90085-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30441

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Title

Liver procollagen prolyl hydroxylase in Opisthorchis viverrini infected hamsters after praziquantel administration

Author(s)

Nongporn Hutadilok
 Witaya Thamavit
 E. Suchart Upatham
 Pintip Ruenwongsa

Other Contributor(s)

Mahidol University

Abstract

Infection of hamsters by the human liver fluke Opisthorchis viverrini elevated liver procollagen prolyl hydroxylase activity, reflecting increased collagen biosynthesis. The increase was proportional to the intensity of infection. However, the infected liver procollagen prolyl hydroxylase activity decreased after administration of praziquantel 300 mg kg-1body weight, and approached normal levels two weeks after treatment. In the infected hamsters, praziquantel, at a curative dose, caused a transient increase in serum aminotransferase levels and a small but persistent rise in serum alkaline phosphatase. The drug, however, did not cause changes in these enzyme activities in the uninfected hamsters. © 1983.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Immunology and Microbiology

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URI

https://repository.li.mahidol.ac.th/handle/123456789/30441

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Scopus 1969-1990
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