Publication: Biocomposite of hydroxyapatite-titania rods (HApTiR): Physical properties and in vitro study
Issued Date
2013-01-01
Resource Type
ISSN
09284931
Other identifier(s)
2-s2.0-84869097046
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Materials Science and Engineering C. Vol.33, No.1 (2013), 251-258
Suggested Citation
Weeraphat Pon-On, Narattaphol Charoenphandhu, I. Ming Tang, Jarinthorn Teerapornpuntakit, Jirawan Thongbunchoo, Nateetip Krishnamra Biocomposite of hydroxyapatite-titania rods (HApTiR): Physical properties and in vitro study. Materials Science and Engineering C. Vol.33, No.1 (2013), 251-258. doi:10.1016/j.msec.2012.08.037 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31783
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Biocomposite of hydroxyapatite-titania rods (HApTiR): Physical properties and in vitro study
Other Contributor(s)
Abstract
The aim in this research is to study the physical and biocompatible properties of hydroxyapatite (HAp) composites (HApTiR) having different amounts of titania rod (TiR) in them (10-90 wt.%). The HAp and TiR were produced using hydrothermal and co-precipitation under reflux methods, respectively. The physical properties and the in vitro biocompatibility of the composites to simulated body fluid (SBF) were investigated. They were also cultured with rat osteoblast-like UMR-106 cells. The synthesized powder showed a core-shell structure with the titania rod as the core and the apatite as the shell. The hardness of the composites of HApTiR's whisker increased from 74.8 to 92.9 MPa as the TiR content was increased from 10 to 90 wt.%. Mineralization study in SBF showed the formation of apatite crystals on the HApTiR's surface after 7 days of incubation. In vitro cell adhesion tests confirmed the osteoblast attachment and growth on the HApTiR's surface. The density of cells, spread and the production of calcium nodules on the substrate were seen to increase with increasing TiR contents except for HApTiR90 (TiR = 90 wt.%) which exhibited lesser growth. MTT tests on HApTiR70 indicated that UMR-106 cells were viable and the density of cells on the substrate was seen to increase with increasing culturing time. © 2012 Elsevier B.V.