Publication: Safety and immunogenicity of different immunization regimens of cvd 103-hgr live oral cholera vaccine in soldiers and civilians in thailand
Issued Date
1992-01-01
Resource Type
ISSN
15376613
00221899
00221899
Other identifier(s)
2-s2.0-0026596515
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.165, No.6 (1992), 1042-1048
Suggested Citation
Pisit Su-Arehawaratana, Preecha Singharaj, David N. Taylor, Charles Hoge, Andrew Trofa, Krit Kuvanont, Sricharoen Migasena, Punnee Pitisuttitham, Yu Leung Lim, Genevieve Losonsky, James B. Kaper, Steven S. Wasserman, Stanley Cryz, Peter Echeverria, Myron M. Levine Safety and immunogenicity of different immunization regimens of cvd 103-hgr live oral cholera vaccine in soldiers and civilians in thailand. Journal of Infectious Diseases. Vol.165, No.6 (1992), 1042-1048. doi:10.1093/infdis/165.6.1042 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22501
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Title
Safety and immunogenicity of different immunization regimens of cvd 103-hgr live oral cholera vaccine in soldiers and civilians in thailand
Abstract
Attenuated Vibrio cholerae oral vaccine CVD 103-HgR was well tolerated by 324 Thai soldiers and civilians. Most received a single 5 × 10(r) cfu dose, while 40 each received one or two 5 × 109cfu doses. Vibriocidal antibody (the best correlate of immunity) seroconversion was lower in soldiers than civilians (P <.001). Increasing the vaccine dose to 5 × 109cfu raised the geometric mean titer (P <.001). A second 5 × 109cfu dose one week later did not notably increase serocon- versions. Likelihood of seroconversion was inversely correlated with baseline vibriocidal titer (P <.001). CVD 103-HgR caused seroconversion in most subjects with baseline titers <1:40, including 100% of civilians after one 5 × 10(r) cfu dose, 79% of soldiers after one 5 × 109cfu dose, and 45% of soldiers after one 5 × 10scfu dose. In persons with elevated baseline titers, vibriocidal antibody seroconversion is not a sensitive measure of whether vaccine has boosted intestinal immunity; for such subjects, other measurements must be used. Study regimens in endemic areas should use a single 5 × 109cfu dose. © 1992 The University of Chicago.