Publication: Antimicrobial, antimalarial, and cytotoxic substances from the insect pathogenic fungus Beauveria asiatica BCC 16812
Issued Date
2021-06-01
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ISSN
18767486
18743900
18743900
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2-s2.0-85102048142
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytochemistry Letters. Vol.43, (2021), 8-15
Suggested Citation
Jittra Kornsakulkarn, Thapanee Pruksatrakul, Panida Surawatanawong, Chattawat Thangsrikeattigun, Somjit Komwijit, Nattawut Boonyuen, Chawanee Thongpanchang Antimicrobial, antimalarial, and cytotoxic substances from the insect pathogenic fungus Beauveria asiatica BCC 16812. Phytochemistry Letters. Vol.43, (2021), 8-15. doi:10.1016/j.phytol.2021.03.003 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/75664
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Title
Antimicrobial, antimalarial, and cytotoxic substances from the insect pathogenic fungus Beauveria asiatica BCC 16812
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Abstract
Six new compounds 1–6 and two new naturally occurring compounds 7 and 8, together with nine known compounds 9–14, beauverioride I, dipicolinic acid, and 6-(methoxycarbonyl) picolinic acid were isolated from a wasp-pathogenic fungus Beauveria asiatica, strain BCC 16812. Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compound 6 were established by the application of modified Mosher's method and ECD calculation. Compounds 9–11 exhibited antimalarial (IC50 0.47–1.79 u g/mL), antimicrobial (MIC 3.13–50.0 u g/mL), and cytotoxic (IC50 0.26–1.23 u g/mL) activities, while compounds 1, 2, 8, and 14 showed only cytotoxicity against Vero cell lines, with IC50 values range 12.96–47.03 u g/mL.