Publication: Stereoselective pharmacokinetics of mefloquine in young children
Issued Date
1996-06-03
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ISSN
00316970
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2-s2.0-0029989825
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Clinical Pharmacology. Vol.50, No.3 (1996), 241-244
Suggested Citation
A. Bourahla, C. Martin, F. Gimenez, V. Singhasivanon, P. Attanath, A. Sabchearon, T. Chongsuphajaisiddhi, R. Farinotti Stereoselective pharmacokinetics of mefloquine in young children. European Journal of Clinical Pharmacology. Vol.50, No.3 (1996), 241-244. doi:10.1007/s002280050100 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17729
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Title
Stereoselective pharmacokinetics of mefloquine in young children
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Abstract
Objective: the stereospecificity of mefloquine pharmacokinetics in children has been investigated. Patients: Twelve children aged 6 to 24 months were treated for uncomplicated falciparum malaria with a single oral dose of 25 mg · kg-1 racemic mefloquine in combination with sulfadoxine and pyrimethamine. Methods: concentrations of mefloquine enantiomers were determined using a coupled achiral-chiral chromatographic system. Pharmacokinetic parameters were calculated using model-independent analysis. Results: Maximum plasma concentrations, areas under the curve and apparent plasma elimination half-lives were higher for the (-) enantiomer than its antipode. In contrast, the apparent volume of distribution (V/f) and total clearance (Cl/f) values were higher for the (+) enantiomer. Conclusion: the stereoselectivity of mefloquine pharmacokinetics is similar to that observed in adults.