Publication: Nicotine-magnesium aluminum silicate microparticle surface modified with chitosan for mucosal delivery
Issued Date
2013-04-01
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ISSN
09284931
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2-s2.0-84873407150
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Mahidol University
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SCOPUS
Bibliographic Citation
Materials Science and Engineering C. Vol.33, No.3 (2013), 1727-1736
Suggested Citation
Watchara Kanjanakawinkul, Thomas Rades, Satit Puttipipatkhachorn, Thaned Pongjanyakul Nicotine-magnesium aluminum silicate microparticle surface modified with chitosan for mucosal delivery. Materials Science and Engineering C. Vol.33, No.3 (2013), 1727-1736. doi:10.1016/j.msec.2012.12.086 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31758
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Title
Nicotine-magnesium aluminum silicate microparticle surface modified with chitosan for mucosal delivery
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Abstract
Magnesium aluminum silicate (MAS), a negatively charged clay, and nicotine (NCT), a basic drug, can interact electrostatically to form microparticles. Chitosan (CS) was used for the surface modification of the microparticles, and a lyophilization method was used to preserve the original particle morphology. The microparticles were characterized in terms of their physicochemical properties, NCT content, mucoadhesive properties, and release and permeation across porcine esophageal mucosa. The results showed that the microparticles formed via electrostatic interaction between MAS and protonated NCT had an irregular shape and that their NCT content increased with increasing NCT ratios in the microparticle preparation solution. High molecular weight CS (800 kDa) adsorbed to the microparticle surface and induced a positive surface charge. CS molecules intercalated into the MAS silicate layers and decreased the crystallinity of the microparticles, leading to an increase in the release rate and diffusion coefficient of NCT from the microparticles. Moreover, the microparticle surface modified with CS was found to have higher NCT permeation fluxes and mucoadhesive properties, which indicated the significant role of CS for NCT mucosal delivery. However, the enhancement of NCT permeation and of mucoadhesive properties depended on the molecular weight and concentration of CS. These findings suggest that NCT-MAS microparticle surface modified with CS represents a promising mucosal delivery system for NCT. © 2012 Elsevier B.V. All Rights Reserved.