Publication:
Attempted vaccination of jirds (Meriones unguiculatus) against Brugia pahangi with radiation attenuated infective larvae

Issued Date

1986-01-01

Resource Type

Article

ISSN

14752697
0022149X

DOI

10.1017/S0022149X00008397

Other identifier(s)

2-s2.0-0022900099

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Helminthology. Vol.60, No.2 (1986), 149-155

Suggested Citation

W. Chusattayanond, D. A. Denham Attempted vaccination of jirds (Meriones unguiculatus) against Brugia pahangi with radiation attenuated infective larvae. Journal of Helminthology. Vol.60, No.2 (1986), 149-155. doi:10.1017/S0022149X00008397 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9652

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Title

Attempted vaccination of jirds (Meriones unguiculatus) against Brugia pahangi with radiation attenuated infective larvae

Author(s)

W. Chusattayanond
 D. A. Denham

Other Contributor(s)

Mahidol University
 London School of Hygiene & Tropical Medicine

Abstract

Jirds were vaccinated by three to five subcutaneous (SC) injections of infective larvae of Brugia pahangi which had been irradiated at 25, 45 or 90 krads from a 60 Co source. They were challenged either SC or intraperitoneally. Vaccination with four doses of 50 larvae irradiated with 25 krads produced 49·3% resistance to IP challenge worms and 39·8% against SC challenge worms. Five doses of larvae irradiated with 45 krads produced 62% resistance to SC challenge. Three doses of larvae irradiated with 90 krads produced 74·9% resistance to SC challenge and five doses produced 76·2% resistance. The reasons why irradiated larvae produce resistance whereas normal larvae do not are discussed. © 1986, Cambridge University Press. All rights reserved.

Keyword(s)

Agricultural and Biological Sciences
 Immunology and Microbiology

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/9652

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Scopus 1969-1990