Publication:
MRSA carriage in a tertiary governmental hospital in Thailand: Emphasis on prevalence and molecular epidemiology

dc.contributor.authorT. Jariyasethpongen_US
dc.contributor.authorC. Tribuddharaten_US
dc.contributor.authorS. Dejsirilerten_US
dc.contributor.authorA. Kerdsinen_US
dc.contributor.authorP. Tishyadhigamaen_US
dc.contributor.authorS. Rahuleen_US
dc.contributor.authorP. Sawanpanyalerten_US
dc.contributor.authorP. Yosapolen_US
dc.contributor.authorN. Aswapokeeen_US
dc.contributor.otherRajavithi Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.date.accessioned2018-09-24T09:24:07Z
dc.date.available2018-09-24T09:24:07Z
dc.date.issued2010-08-01en_US
dc.description.abstractWe investigated prevalence and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) in a case-control study performed in a 900-bed tertiary governmental healthcare facility in Bangkok, Thailand. Multivariate unconditional logistic regression was used to identify risk profiles for MRSA carriage. Phage typing, pulsed-field gel electrophoresis (PFGE), polymorphisms of the coa and spa genes, hypervariable region (HVR) of SCCmec, multi-locus sequence typing (MLST), and identification of ST30/ST8 mosaic chromosome by heteroduplex-polymerase chain reaction (heteroduplex-PCR) were used to demonstrate a clonal relationship. Fifty-seven of 619 in-patients (9.2%) were positive for MRSA. Risk factors were being male, long admission, low modified McCabe score, history of MRSA infection, and use of broad spectrum cephalosporin. Molecular typing results indicated close relatedness among MRSA isolates. Successful epidemic subtypes were recovered from many different wards. However, all subtypes with different multi-locus sequence types were single locus variants (SLVs) of ST239. Heteroduplex-PCR gave two positive bands from ST8/ST30 mosaic chromosomal structures in all SLVs indicating all isolates were of the ST239 origin. The burden of MRSA nosocomial infections is high in the governmental tertiary hospital. The sole ST239 and its SLVs identified in this hospital is striking and calls for better policy for infection control and prevention. © 2010 Springer-Verlag.en_US
dc.identifier.citationEuropean Journal of Clinical Microbiology and Infectious Diseases. Vol.29, No.8 (2010), 977-985en_US
dc.identifier.doi10.1007/s10096-010-0954-7en_US
dc.identifier.issn09349723en_US
dc.identifier.other2-s2.0-77955473163en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/29584
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955473163&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleMRSA carriage in a tertiary governmental hospital in Thailand: Emphasis on prevalence and molecular epidemiologyen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955473163&origin=inwarden_US

Files

Collections