Publication:
Different molecular defects of <sup>G</sup>γ (<sup>A</sup>γδβ)°‐thalassaemia in Thailand

Issued Date

1987-01-01

Resource Type

Article

ISSN

16000609
09024441

DOI

10.1111/j.1600-0609.1987.tb00746.x

Other identifier(s)

2-s2.0-0023388555

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

European Journal of Haematology. Vol.39, No.2 (1987), 154-160

Suggested Citation

S. Fucharoen, P. Winichagoon, S. Chaicharoen, P. Wasi Different molecular defects of <sup>G</sup>γ (<sup>A</sup>γδβ)°‐thalassaemia in Thailand. European Journal of Haematology. Vol.39, No.2 (1987), 154-160. doi:10.1111/j.1600-0609.1987.tb00746.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15444

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Title

Different molecular defects of <sup>G</sup>γ (<sup>A</sup>γδβ)°‐thalassaemia in Thailand

Author(s)

S. Fucharoen
 P. Winichagoon
 S. Chaicharoen
 P. Wasi

Other Contributor(s)

Mahidol University

Abstract

DNA from members of 2 Thai families with conditions considered to be δβ‐thalassaemia were studied by using restriction endonuclease DNA mapping. The propositus in family A is a double heterozygote for β‐thalassaemia and δβ‐thalassaemia. DNA analysis reveals a deletion of the β‐globin gene cluster starting at the area between the Sac I and Eco RI sites near the 3′ end of the G γ‐gene and extending through the A γ‐, δ‐ and β‐genes to an unknown extent downstream. In family B, the propositus is δβ‐thalassaemia/Hb E. Deletion of the β‐globin gene cluster begins in the large intervening sequence of the A γ‐gene and removes both δ‐ and β‐genes downstream. © Munksgaard 1987

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/15444

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Scopus 1969-1990