Publication: Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections
Issued Date
2021-12-01
Resource Type
ISSN
20452322
Other identifier(s)
2-s2.0-85120872476
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Mahidol University
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SCOPUS
Bibliographic Citation
Scientific Reports. Vol.11, No.1 (2021)
Suggested Citation
Karina Doris Vihta, Nicola Claire Gordon, Nicole Stoesser, T. Phuong Quan, Carina S.B. Tyrrell, Manivanh Vongsouvath, Elizabeth A. Ashley, Vilada Chansamouth, Paul Turner, Clare L. Ling, David W. Eyre, Nicholas J. White, Derrick Crook, Tim E.A. Peto, Ann Sarah Walker Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections. Scientific Reports. Vol.11, No.1 (2021). doi:10.1038/s41598-021-02755-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/79190
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Title
Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections
Other Contributor(s)
Faculty of Tropical Medicine, Mahidol University
National Institute for Health Research
Oxford University Hospitals NHS Foundation Trust
London School of Hygiene & Tropical Medicine
University of Cambridge
Mahosot Hospital, Lao
Nuffield Department of Medicine
John Radcliffe Hospital
Angkor Hospital for Children
National Institute for Health Research
Oxford University Hospitals NHS Foundation Trust
London School of Hygiene & Tropical Medicine
University of Cambridge
Mahosot Hospital, Lao
Nuffield Department of Medicine
John Radcliffe Hospital
Angkor Hospital for Children
Abstract
Antimicrobial resistance (AMR) surveillance in bloodstream infections (BSIs) is challenging in low/middle-income countries (LMICs) given limited laboratory capacity. Other specimens are easier to collect and process and are more likely to be culture-positive. In 8102 E. coli BSIs, 322,087 E. coli urinary tract infections, 6952 S. aureus BSIs and 112,074 S. aureus non-sterile site cultures from Oxfordshire (1998–2018), and other (55,296 isolates) rarer commensal opportunistic pathogens, antibiotic resistance trends over time in blood were strongly associated with those in other specimens (maximum cross-correlation per drug 0.51–0.99). Resistance prevalence was congruent across drug-years for each species (276/312 (88%) species-drug-years with prevalence within ± 10% between blood/other isolates). Results were similar across multiple countries in high/middle/low income-settings in the independent ATLAS dataset (103,559 isolates, 2004–2017) and three further LMIC hospitals/programmes (6154 isolates, 2008–2019). AMR in commensal opportunistic pathogens cultured from BSIs is strongly associated with AMR in commensal opportunistic pathogens cultured from non-sterile sites over calendar time, suggesting the latter could be used as an effective proxy for AMR surveillance in BSIs.