Publication: Antidiabetic effects of Maclura cochinchinensis (Lour.) corner heartwood extract
6
Issued Date
2019-01-01
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ISSN
22254110
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2-s2.0-85074153611
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Traditional and Complementary Medicine. (2019)
Suggested Citation
Savita Chewchinda, Nantakarn Leakaya, Hitoshi Sato, Vilasinee Hirunpanich Sato Antidiabetic effects of Maclura cochinchinensis (Lour.) corner heartwood extract. Journal of Traditional and Complementary Medicine. (2019). doi:10.1016/j.jtcme.2019.10.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/52045
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Title
Antidiabetic effects of Maclura cochinchinensis (Lour.) corner heartwood extract
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Abstract
© 2019 Center for Food and Biomolecules, National Taiwan University Background and aim: Maclura cochinchinensis (MC) (Lour.) heartwood extract have been used traditionally to treat diabetes in Thailand, but their mechanism of action has not been elucidated. Experimental procedure: This study investigated the effects of an aqueous heartwood extract of MC on α-glucosidase and α-amylase activities. Moreover, its antidiabetic effect was evaluated using an oral glucose tolerance test (OGTT) and a 28-day administration to streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic mice. Results: In both OGTT and the daily oral administration for 28 days in STZ-NA-induced type 2 diabetic mice models, the extract (1,000 mg/kg) significantly decreased fasting blood glucose. This hypoglycemic effect was explained by increased insulin levels and α-glucosidase inhibition (IC50:1.53 ± 0.03 μg/mL). Conclusion: This first study on the hypoglycemic activity of MC heartwood extract indicates that it could be a potential natural remedy for type 2 diabetes.