Publication: Behavior Problems and Cognitive Function in Pediatric Liver Transplant Recipients
Issued Date
2021-03-01
Resource Type
ISSN
18732623
00411345
00411345
Other identifier(s)
2-s2.0-85099628774
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transplantation Proceedings. Vol.53, No.2 (2021), 649-655
Suggested Citation
Songpon Getsuwan, Jariya Chuthapisith, Suporn Treepongkaruna, Napapat Butsriphum, Wasuntara Prabpram, Chutima Charoenthanakit, Pornthep Tanpowpong, Chatmanee Lertudomphonwanit Behavior Problems and Cognitive Function in Pediatric Liver Transplant Recipients. Transplantation Proceedings. Vol.53, No.2 (2021), 649-655. doi:10.1016/j.transproceed.2020.10.041 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78411
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Behavior Problems and Cognitive Function in Pediatric Liver Transplant Recipients
Other Contributor(s)
Abstract
Background: Liver transplant (LT) is a lifesaving treatment providing excellent clinical outcomes. However, data regarding behavioral and cognitive issues after LT are sparse in Asia. This study aimed to investigate behavior and cognitive problems among pediatric LT recipients. Methods: We used the Child Behavior Checklist (CBCL) to evaluate behavior problems and/or the Wechsler Intelligence Scale for Children, Third Edition (WISC-III) to assess cognitive function. Participants were children aged 2 to 18 years who were treated with LT for at least 2 years. Results: We included 77 children with a median age of 7.8 years (interquartile range, 5.0-10.9). All children were evaluated with the CBCL, and 26 children were available for WISC-III assessment. Approximately one-third (34%) of the children had a total CBCL score above a clinical cutoff for significant behavior problems, and 29% of school-aged children had abnormal competence scores in a clinically significant range. Most of the evaluated children (17 of 26; 65%) had a normal full-scale intelligence quotient. Lower cognitive function was associated with having a single parent (P < .01). Higher behavior problems were associated with lower parental education level (P = .01) and correlated with longer post-transplant duration (Spearman's rho = 0.443; P < .001). Conclusions: Significant numbers of children have behavior problems after LT. Most children have normal cognitive function, although a larger sample size is required to confirm this result. Long-term support for cognitive and behavior problems after LT should be implemented, particularly in children with single parents and lower parental education level.