Publication: Nanotechnology, mitochondria, and cancer: Mitochondria-targeting particles for biomedical applications
Issued Date
2021-01-01
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2-s2.0-85126047341
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Mahidol University
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SCOPUS
Bibliographic Citation
Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine. (2021), 291-310
Suggested Citation
Amaraporn Wongrakpanich, Jiraphong Suksiriworapong, Sean M. Geary, Phawanan Sawangchan, Janjira Intra, Uracha Ruktanonchai, Aliasger K. Salem Nanotechnology, mitochondria, and cancer: Mitochondria-targeting particles for biomedical applications. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine. (2021), 291-310. doi:10.1016/B978-0-323-85666-9.00013-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76312
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Nanotechnology, mitochondria, and cancer: Mitochondria-targeting particles for biomedical applications
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Abstract
Mitochondria have become a promising target for prevention and treatment of various diseases such as Alzheimer’s disease, Parkinson’s disease, ischemia-reperfusion injury, diabetes, obesity, and especially cancer. As a result, recent research has been focused on targeting mitochondria. To impact on mitochondrial functions, drug molecules need to be able to selectively travel to mitochondria and overcome barriers such as the cell membrane and mitochondrial membrane. This can be enhanced through various delivery systems which include liposomes, polymeric particles, and inorganic particles. These delivery systems are often decorated with mitochondriotropic moieties such as triphenylphosphonium and dequalinium. Here, we provide an overview of the various nanoparticle- and microparticle-based strategies used to deliver drugs to mitochondria.