Publication: Case-control studies on host factors in severe malaria
Issued Date
2001-07-04
Resource Type
ISSN
14714922
Other identifier(s)
2-s2.0-0034983108
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Trends in Parasitology. Vol.17, No.6 (2001), 253-254
Suggested Citation
Mathieu Nacher, Pratap Singhasivanon, Frédérick Gay, Udomsak Silachamroon, Sornchai Looareesuwan Case-control studies on host factors in severe malaria. Trends in Parasitology. Vol.17, No.6 (2001), 253-254. doi:10.1016/S1471-4922(01)01926-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26565
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Case-control studies on host factors in severe malaria
Other Contributor(s)
Abstract
Although molecular biology has illustrated the phenotypic heterogeneity of Plasmodium falciparum, there are still no specific markers of virulence. As parasite virulence is an important determinant of severe malaria, the choice of comparison groups in the study of host factors influencing severity is a delicate issue. Ignoring parasite factors in the selection of controls potentially leads to biased comparisons between a majority of cases with virulent parasites and a majority of controls with non-virulent parasites. This article discusses how to avoid this virulence bias in the absence of specific markers of virulence.