Publication: Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia
Issued Date
2019-01-01
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ISSN
24498238
23921099
23921099
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2-s2.0-85065212127
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Experimental Hepatology. Vol.5, No.1 (2019), 48-54
Suggested Citation
Kanjaporn Sirisomboonlarp, Wanvisa Udomsinprasert, Ellie McConachie, Thamonwan Woraruthai, Yong Poovorawan, Sittisak Honsawek Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia. Clinical and Experimental Hepatology. Vol.5, No.1 (2019), 48-54. doi:10.5114/ceh.2019.83156 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/52319
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Title
Increased serum glypican-3 is associated with liver stiffness and hepatic dysfunction in children with biliary atresia
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Abstract
© 2019 Termedia Publishing House Ltd. All rights reserved. Aim of the study: Biliary atresia (BA) is an uncommon disorder of the liver and bile ducts affecting infants and is characterized by progressive fibrosclerosing obstruction of the extrahepatic biliary tree leading to end-stage liver failure. The purpose of this study was to determine serum glypican-3 (GPC3) levels and liver stiffness in children with BA and the correlation of glypican-3 with clinical parameters. Material and methods: Seventy-five post-Kasai BA patients and 28 healthy age-matched controls were registered. Serum GPC3 levels were examined by enzyme-linked immunosorbent assay. Liver stiffness measurement was analyzed by transient elastography. Results: BA patients had significantly greater serum GPC3 and liver stiffness values than controls (p < 0.001). Serum GPC3 and liver stiffness values were significantly higher in jaundiced BA patients than in non-jaundiced BA patients (p < 0.001). Additionally, serum glypican-3 was associated with liver stiffness and serum total bilirubin (p < 0.001, respectively). Conclusions: Elevated serum GPC3 levels were associated with hepatic dysfunction and the severity of BA. As a result, serum GPC3 and liver stiffness might serve as biomarkers reflecting the deterioration of hepatic function and the outcome in post-Kasai BA.