Publication: Serum TGF-β1 in atopic asthma
Issued Date
2008-12-01
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ISSN
0125877X
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2-s2.0-64249085557
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.26, No.4 (2008), 185-189
Suggested Citation
Wiparat Manuyakorn, Wasu Kamchaisatian, Kalayanee Atamasirikul, Cherapat Sasisakulporn, Chalerat Direkwattanachai, Suwat Benjaponpitak Serum TGF-β1 in atopic asthma. Asian Pacific Journal of Allergy and Immunology. Vol.26, No.4 (2008), 185-189. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19256
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Title
Serum TGF-β1 in atopic asthma
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Abstract
Asthma is a chronic inflammatory disease of the airway. Pathological repair of chronic inflammation leads to airway remodeling. Transforming growth factor-β (TGF-β), a profibrotic cytokine, plays an important role in promoting the structural changes of airway remodeling. TGF-β effects on the proliferation, differentiation and extracellular matrix (ECM) metabolism of airway structural cells. This study assessed serum TGF-β1 in different severity of atopic asthma compared to non-atopic controls. Thirty-one atopic asthmatic patients and 34 non-atopic controls, aged 7-18 years, were recruited as to the asthma severity: steroid native mild asthma, moderate asthma, and asthma in remission. Serum TGF-β1 was measured by enzyme-linked immunosorbent assay. There was a significant difference between serum TGF-β1 in asthmatic patients and that in control patients (39.59 ng/ ml vs. 0.26 ng/ml, p < 0.001). Serum TGF-β1 was highest in steroid native mild asthma group when compared to the moderate asthma and asthma in remission groups (47.44 ng/ml vs. 38.64 ng/ml and 47.44 ng/ml vs. 35.94 ng/ml, p = 0.013 and 0.001, respectively). There were no correlations among serum TGF-β1 and pulmonary function test parameters, duration of asthma, and duration of inhaled corticosteroid treatment. These data support the role of TGF-β1 in airway remodeling in asthma.