Publication: Intestinal Calcium Absorption
Issued Date
2021-07-01
Resource Type
ISSN
20404603
Other identifier(s)
2-s2.0-85107320085
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Mahidol University
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SCOPUS
Bibliographic Citation
Comprehensive Physiology. Vol.11, No.3 (2021), 2047-2073
Suggested Citation
Kannikar Wongdee, Krittikan Chanpaisaeng, Jarinthorn Teerapornpuntakit, Narattaphol Charoenphandhu Intestinal Calcium Absorption. Comprehensive Physiology. Vol.11, No.3 (2021), 2047-2073. doi:10.1002/cphy.c200014 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76124
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Title
Intestinal Calcium Absorption
Abstract
In this article, we focus on mammalian calcium absorption across the intestinal epithelium in normal physiology. Intestinal calcium transport is essential for supplying calcium for metabolism and bone mineralization. Dietary calcium is transported across the mucosal epithelia via saturable transcellular and nonsaturable paracellular pathways, both of which are under the regulation of 1,25-dihydroxyvitamin D3 and several other endocrine and paracrine factors, such as parathyroid hormone, prolactin, 17β-estradiol, calcitonin, and fibroblast growth factor-23. Calcium absorption occurs in several segments of the small and large intestine with varying rates and capacities. Segmental heterogeneity also includes differential expression of calcium transporters/carriers (e.g., transient receptor potential cation channel and calbindin-D9k) and the presence of favorable factors (e.g., pH, luminal contents, and gut motility). Other proteins and transporters (e.g., plasma membrane vitamin D receptor and voltage-dependent calcium channels), as well as vesicular calcium transport that probably contributes to intestinal calcium absorption, are also discussed.