Publication: Effects of cigarette smoking on duodenal ulcer healing and relapse rate.
Issued Date
1994-11-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-0028537936
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Vol.77, No.11 (1994), 566-571
Suggested Citation
S. Boonyapisit, S. Manatsathit, U. Kachintorn, T. Tanwandee, Y. Sattawatthamrong, O. Chinapak Effects of cigarette smoking on duodenal ulcer healing and relapse rate.. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. Vol.77, No.11 (1994), 566-571. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9628
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Title
Effects of cigarette smoking on duodenal ulcer healing and relapse rate.
Other Contributor(s)
Abstract
104 duodenal ulcer patients were classified into non-smokers (76) and smokers (28). Their age range was between 14-72 years. They were randomly treated with cimetidine (28 non-smokers and 8 smokers), colloidal bismuth (27 non-smokers and 10 smokers) and sucralfate (21 non-smokers and 10 smokers). Follow-up endoscopic examination at 4, 6 and 8 weeks showed that overall healing rates were better in the non-smokers than in the smokers (64.5% against 46.4% at 4 weeks and 92.1% against 67.8% at 6 weeks) and almost all ulcers had healed at the end of 8 weeks (100% in non-smokers and 96.4% in smokers). Among non-smokers, there were no statistically significant differences in the healing rates by any medication at any period of time. Among smokers, colloidal bismuth had significant better healing rate at 6 weeks over cimetidine and sucralfate. (p = 0.04 and p = 0.041 respectively). Overall relapse rates were higher among smokers (32.1%) than non-smokers (10.5%). Of the 3 medications, sucralfate had the lowest relapse rate in both smokers (20%) and non-smokers (9.5%), while colloidal bismuth had the highest relapse rates (40% for smokers and 11.1% for non-smokers).