Publication: Red blood cell vesicles in thalassemia
Issued Date
2004-03-01
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ISSN
01252208
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2-s2.0-2642563643
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.87, No.3 (2004), 233-238
Suggested Citation
Pornvaree Lamchiagdhase, Chitsinee Rattanapong, Surada Lerdwana, Rumaneeya Nitipongwanich, Egarit Noulsri, Kovit Pattanapanyasat Red blood cell vesicles in thalassemia. Journal of the Medical Association of Thailand. Vol.87, No.3 (2004), 233-238. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21697
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Title
Red blood cell vesicles in thalassemia
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Abstract
Vesicles are part of the red blood cells membrane which can be found in a small number in normal apoptotic process and increased in some diseases. In the present study, the authors measured the percentage of red blood cell vesicles in healthy subjects (n = 7), patients with α-thalassemia or Hemoglobin (Hb) H disease (n = 7), β-thal/Hb E with nonsplenectomized (n = 5) and splenectomized (n = 7) before and after induction heated at 48.6°C by using flow cytometry. It was found that the percentage of vesicles in every group were not statistically significantly different (p > 0.05) between pre and post incubation at 5 min. The percentage of vesicles of healthy subjects, β-thal/Hb E nonsplenectomized patients and splenectomized patients were highest when induced by heating for 60 min. For patients with Hb H disease, the percentage of vesicles was maximum at 30 min when compared with healthy subjects, β-thal/Hb E nonsplenectomized patients and splenectomized patients, respectively. In the present study, the authors report the significant increase of the percentage of vesicles in Hb H disease, β-thal/Hb E nonsplenectomized and splene'ctomized after induction by heat when compared with healthy subjects. These findings may support the different pathology of the red blood cells found in α- and β-thalassemia.