Publication: Microsatellite alterations in non-small cell lung cancer
Issued Date
2002-04-25
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ISSN
03929078
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2-s2.0-0036225992
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Experimental and Clinical Cancer Research. Vol.21, No.1 (2002), 31-35
Suggested Citation
Songsak Petmitr, S. Nuchfaong, P. Chaksangchaichot, W. Pongstaporn, P. Sutinont, T. Limsila, P. Punyarit Microsatellite alterations in non-small cell lung cancer. Journal of Experimental and Clinical Cancer Research. Vol.21, No.1 (2002), 31-35. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20067
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Title
Microsatellite alterations in non-small cell lung cancer
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Abstract
Genetic alterations at 12 dinucleotide repeat loci located on human chromosomes 2, 3, 12, and 17 have been analyzed in non-small cell lung cancer from Thai patients. Seventeen out of 30 cases (57%) harbored the microsatellite alterations. Of the 30 cases, 19 patients had a history of tobacco smoking, of whom 14 (74%) were in the group with microsatellite alterations, whereas 3 out of 11 non-smokers (26%) had these alterations. The frequency of microsatellite alterations among smokers was significantly higher than it was in non-smokers (P = 0.01 Fisher's exact test; odds ratio; 7.47).