Publication: The enigmatic reaction of flavins with oxygen
Issued Date
2012-09-01
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ISSN
09680004
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2-s2.0-84865435786
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Mahidol University
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SCOPUS
Bibliographic Citation
Trends in Biochemical Sciences. Vol.37, No.9 (2012), 373-380
Suggested Citation
Pimchai Chaiyen, Marco W. Fraaije, Andrea Mattevi The enigmatic reaction of flavins with oxygen. Trends in Biochemical Sciences. Vol.37, No.9 (2012), 373-380. doi:10.1016/j.tibs.2012.06.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13621
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Title
The enigmatic reaction of flavins with oxygen
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Abstract
The reaction of flavoenzymes with oxygen remains a fascinating area of research because of its relevance for reactive oxygen species (ROS) generation. Several exciting recent studies provide consistent mechanistic clues about the specific functional and structural properties of the oxidase and monooxygenase flavoenzymatic systems. Specifically, the spatial arrangement of the reacting oxygen that is in direct contact with the flavin group is emerging as a crucial factor that differentiates between oxidase and monooxygenase enzymes. A challenge for the future will be to use these emerging concepts to rationally engineer flavoenzymes, paving the way to new research avenues with far-reaching implications for oxidative biocatalysis and metabolic engineering. © 2012 Elsevier Ltd.