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Crystallinity of omeprazole in various film polymers

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dc.contributor.authorNarong Sarisutaen_US
dc.contributor.authorMont Kumpugdeeen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-07T09:26:11Z
dc.date.available2018-09-07T09:26:11Z
dc.date.issued2000-01-01en_US
dc.description.abstractThe crystallinity of omeprazole in six film-forming polymers, Eudragit L100, shellac, polyvinyl acetate phthalate, cellulose acetate phthalate, hydroxypropyl methylcellulose acetate phthalate and hydroxypropyl methylcellulose (HPMC) was determined. Polymer films containing omeprazole were prepared by casting and characterized using powder X-ray diffractometry, Fourier transform infrared spectroscopy, and differential scanning calorimetry. Omeprazole powder recrystallized from all solvents studied were similar to the original powder. The drug existed as the amorphous form in the five acid polymers whereas its crystalline form appeared in nonionic polymer HPMC. No evidence of a drug-polymer interaction was found. Omeprazole exists in amorphous form in polymers most commonly used in enteric film-coated formulations.en_US
dc.identifier.citationPharmacy and Pharmacology Communications. Vol.6, No.1 (2000), 7-11en_US
dc.identifier.doi10.1211/146080800128735403en_US
dc.identifier.issn14608081en_US
dc.identifier.other2-s2.0-0034106091en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/26364
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034106091&origin=inwarden_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleCrystallinity of omeprazole in various film polymersen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0034106091&origin=inwarden_US

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