Publication: Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates
Issued Date
2009-05-08
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ISSN
03400131
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2-s2.0-67649321640
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Mahidol University
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SCOPUS
Bibliographic Citation
International Archives of Occupational and Environmental Health. Vol.82, No.7 (2009), 833-842
Suggested Citation
Sirivarasai Jintana, Kaojarern Sming, Yoovathaworn Krongtong, Sura Thanyachai Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates. International Archives of Occupational and Environmental Health. Vol.82, No.7 (2009), 833-842. doi:10.1007/s00420-009-0422-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28082
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Title
Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates
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Abstract
Objective: Biological monitoring is an essential component for assessing the exposure of individuals to organophosphate pesticides. The aim of this study was to determine cholinesterase activity, pesticide exposure and health effects in the exposed population. Methods: A total of 90 individuals occupationally exposed to OPs and 30 controls were recruited in this study. Erythrocyte acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities were measured in two periods of low- and high-exposure. Results: There were statistically significant decrease in AChE and BuChE activities in the high-exposure period (20.73 ± 0.99 U/gHb and 3.73 ± 0.19 U/mL, respectively, P < 0.001) compared to the low-exposure period (29.81 ± 1.19 U/gHb and 4.92 ± 0.19 U/ mL, respectively). All enzyme activities in the exposed group were statistically lower than in the control group. Analysis of the relation between cholinesterase activity and symptoms showed significant evidences. Conclusions: The results suggested the association between occupational pesticide exposure and inhibition of cholinesterases. Thus, medical monitoring of cholinesterase inhibition and intervention programs regarding safety practices during field work are important issues aimed at minimizing adverse health effects of pesticide. © Springer-Verlag 2009.