Publication: Anthelminthic effects of artemisinin and its derivatives
Issued Date
2013
Resource Type
Language
eng
ISSN
1906-2257
Rights
Mahidol University
Rights Holder(s)
Faculty of Veterinary Science Mahidol University
Bibliographic Citation
Journal of Applied Animal Science. Vol.6, No.1 (2013), 17-26
Suggested Citation
Tawewan Tansatit Anthelminthic effects of artemisinin and its derivatives. Journal of Applied Animal Science. Vol.6, No.1 (2013), 17-26. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13325
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Thesis
Title
Anthelminthic effects of artemisinin and its derivatives
Alternative Title(s)
ประสิทธิภาพของอาติมิซินินและสารอนุพันธ์ในการใช้เป็นยาถ่ายพยาธิ
Author(s)
Abstract
Qinghao (Artemisia annua, L.), a famous herb from China, has been used in traditional Chinese medicine.
Artemisinin, an active substance is extracted from the leaves and flowers of Qinghao, with a unique
sesquiterpene lactone endoperoxide structure showing an antimalarial activity. Derivatives of artemisinin,
artesunate and artemether, are the most widely used as antimalarial drugs. Since artemisinin not only possess
antimalarial properties, but also active against various parasitic infection. Ongoing research on these
compounds has been emphasized on the potential impact for anthelmintic treatment. Artemisinin derivatives
exhibited a broad spectrum property against various trematodes, nematode, and cestode both in vitro and
in vivo studies. These helminthocidal properties of artemisinin derivatives presented here provide further data
for clinical investigations in the field trial study. However, a better understanding of action of artemisinin
derivatives and their biomolecule target may contribute a promising possibility for clinical utility in
anthelmintic application. Toxicity of artemisinin derivatives was less and was demonstrated in experimental
animals with neurotoxicity and anemia.