Publication: High prevalence of hepatitis G viremia among kidney transplant patients in Thailand
Issued Date
1997-10-01
Resource Type
ISSN
01466615
Other identifier(s)
2-s2.0-0030765912
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Medical Virology. Vol.53, No.2 (1997), 162-166
Suggested Citation
Boonyos Raengsakulrach, Leena Ong-aj-yooth, Thanarak Thaiprasert, Sanga Nilwarangkur, Sompong Ong-aj-yooth, Sumitda Narupiti, Vipa Thirawuth, Chonticha Klungthong, Rapin Snitbhan, David W. Vaughn High prevalence of hepatitis G viremia among kidney transplant patients in Thailand. Journal of Medical Virology. Vol.53, No.2 (1997), 162-166. doi:10.1002/(SICI)1096-9071(199710)53:2<162::AID-JMV9>3.0.CO;2-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17959
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Title
High prevalence of hepatitis G viremia among kidney transplant patients in Thailand
Other Contributor(s)
Abstract
Patients receiving kidney transplants (KT) are at high risk for blood borne viral infections. To determine the prevalence of a recently discovered hepatitis G virus (HGV) in this patient group, reverse transcription-polymerase chain reaction (RT-PCR) employing primers derived from the NS5 region of the viral genome was utilized. HGV RNA was detected in 40 of 94 KT patients (43%), as compared to 3 of 69 healthy subjects (4.3%). Cocirculation of HGV and hepatitis C virus (HCV) RNA was detected in 12 patients (13%). Comparison of patients with and without HGV revealed that the former had received hemodialysis before transplantation for a significantly longer duration than the latter (28 vs. 17 months, respectively; P < 0.05). The amount of blood transfused and mean levels of liver enzymes, including alkaline phosphatase, alanine transaminase, and aspartate transaminase, were the same in both groups. Sequence analysis of 275-base pair DNA clones obtained from 2 patients revealed approximately 92% sequence homology to the published HGV and GB virus C sequences. These results suggested that HGV infection among Thai KT patients was high and the role of HGV in causing liver disease remains to be determined.
