Publication:
Mutually exclusive var gene expression in the malaria parasite: multiple layers of regulation

Issued Date

2008-10-01

Resource Type

Review

ISSN

14714922

DOI

10.1016/j.pt.2008.07.005

Other identifier(s)

2-s2.0-51449122039

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Trends in Parasitology. Vol.24, No.10 (2008), 455-461

Suggested Citation

Thanat Chookajorn, Patrath Ponsuwanna, Liwang Cui Mutually exclusive var gene expression in the malaria parasite: multiple layers of regulation. Trends in Parasitology. Vol.24, No.10 (2008), 455-461. doi:10.1016/j.pt.2008.07.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19289

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Title

Mutually exclusive var gene expression in the malaria parasite: multiple layers of regulation

Author(s)

Thanat Chookajorn
 Patrath Ponsuwanna
 Liwang Cui

Other Contributor(s)

Mahidol University
 Pennsylvania State University

Abstract

As a major factor in Plasmodium falciparum malaria pathogenesis, the var gene family has been the focus of extensive research, which has contributed to our current understanding of Plasmodium antigenic variation. In recent years, sophisticated molecular tools have enabled the generation of interesting data regarding the regulation of mutually exclusive var expression. Although their results are still inconclusive, these studies have demonstrated the existence of multiple layers of control over gene activation, silencing, memory and 'counting'. This review attempts to summarize recent findings and dissect the different layers of var regulation. © 2008 Elsevier Ltd. All rights reserved.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/19289

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Scopus 2006-2010