Publication: Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism
Issued Date
2017-04-01
Resource Type
ISSN
2476762X
15137368
15137368
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2-s2.0-85019628742
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol.18, No.4 (2017), 1117-1120
Suggested Citation
Sarinthorn Rakmanee, Samart Pakakasama, Suradej Hongeng, Sirima Sanguansin, Acharawan Thongmee, Wanida Pongstaporn Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism. Asian Pacific Journal of Cancer Prevention. Vol.18, No.4 (2017), 1117-1120. doi:10.22034/APJCP.2017.18.4.1117 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41935
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Title
Increased risk of Thai childhood acute lymphoblastic leukemia with the MiR196a2 T > C polymorphism
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Abstract
Objectives: This study assessed associations of the miR196a2 (rs11614913) T > C polymorphism withsusceptibility to childhood acute lymphoblastic leukemia (ALL) and clinical outcomes. Materials and Methods: Blood DNA samples from 104 childhood ALL patients and 180 healthy children were studied for the miR-196a2 (rs11614913) polymorphism using a polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) approach. Results: The frequency of the miR-196a2 (rs11614913) T allele in controls was 0.51 compared with 0.33 in ALL cases. In this study, CC, TC heterozygote and CC/TC genotypes were significantly associated with increase childhood ALL susceptibility compared with the TT wild type (OR =4.321, 95% CI = 2.091-8.930 p=0.000, OR = 2.248, 95% CI =1.103-4.579, p=0.024, OR = 2.921, 95% CI = 1.504-5.673 p=0.001, respectively). However, the miR-196a2 (rs11614913) T > C polymorphism was not associated with demographic data or clinico-pathological data in ALL cases. Conclusion: CC, TC and CC+TC genotypes of miR-196a2 (rs11614913) was significantly associated with increased susceptibility in Thai childhood ALL but not with clinical variables.