Publication:
Use of proton pump inhibitors is associated with a higher risk of pneumonia in cirrhotic patients: A systematic review and meta-analysis

dc.contributor.authorWasit Wongtrakulen_US
dc.contributor.authorNipith Charoenngnamen_US
dc.contributor.authorPatompong Ungpraserten_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.date.accessioned2020-06-02T04:54:44Z
dc.date.available2020-06-02T04:54:44Z
dc.date.issued2020-05-09en_US
dc.description.abstract© 2020 Hellenic Society of Gastroenterology. Background Proton pump inhibitors (PPIs) are commonly prescribed for cirrhotic patients. However, the use of PPIs in these patients may increase the risk of bacterial infection. The current study aimed to investigate the risk of developing pneumonia among cirrhotic patients exposed to PPIs. Methods A literature search was independently conducted by 2 investigators using the MEDLINE and EMBASE databases up to September 2019. To be eligible, a study had to be an observational (cohort, case-control or cross-sectional) study that included one group of cirrhotic patients with PPI use and another group of cirrhotic patients without PPI use. Effect estimates of the association between PPI use and pneumonia had to be reported. Point estimates and standard errors from each eligible study were combined together using the generic inverse variance method of DerSimonian and Laird. Results Of 1947 articles identified from the 2 databases, 3 cohort and 5 cross-sectional studies with 40,295 participants met the eligibility criteria and were included in the meta-analysis. The pooled analysis found that cirrhotic patients with a history of PPI use had a significantly higher risk of developing pneumonia than those without PPI use, with a pooled risk ratio of 1.36 (95% confidence interval 1.00-1.85; I2 47%). Conclusion A significantly increased risk of pneumonia among cirrhotic patients exposed to PPIs was demonstrated in this study.en_US
dc.identifier.citationAnnals of Gastroenterology. Vol.33, No.3 (2020), 277-284en_US
dc.identifier.doi10.20524/aog.2020.0483en_US
dc.identifier.issn17927463en_US
dc.identifier.issn11087471en_US
dc.identifier.other2-s2.0-85084360336en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/56236
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85084360336&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleUse of proton pump inhibitors is associated with a higher risk of pneumonia in cirrhotic patients: A systematic review and meta-analysisen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85084360336&origin=inwarden_US

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