Publication: Boosted p24 antigen assay for early diagnosis of perinatal HIV infection
Issued Date
2010-02-01
Resource Type
ISSN
01252208
01252208
01252208
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2-s2.0-77949694743
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.93, No.2 (2010), 187-190
Suggested Citation
Orasri Wittawatmongkol, Nirun Vanprapar, Pimpanada Chearskul, Wanatpreeya Phongsamart, Wasana Prasitsuebsai, Ruengpung Sutthent, Kulkanya Chokephaibulkit Boosted p24 antigen assay for early diagnosis of perinatal HIV infection. Journal of the Medical Association of Thailand. Vol.93, No.2 (2010), 187-190. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29776
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Title
Boosted p24 antigen assay for early diagnosis of perinatal HIV infection
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Abstract
Objective: The authors evaluated the accuracy of in-house boosted-p24 antigen assay for diagnosis of perinatal HIV infection. Material and Method: The author has retrospectively reviewed the medical records of infants born to HIVpositive mothers. The infants were tested for boosted-p24 antigen assay at the age of 1-2 months and 4-6 months. HIV infection was defined as positive anti-HIV at the age 18 months or older, or had positive HIV-PCR with clinical signs and symptoms compatible with HIV/AIDS. Results: There were 168 infants included in this review and six were HIV-infected. The boosted-p24 antigen assay had the sensitivity, specificity, positive predictive value, and negative predictive value of 33.33%, 98.27%, 50%, and 95.8%, respectively at 1-2 month-old, and 100%, 98.27%, 71.43%, and 100%, respectively at 4-6 month-old. Conclusion: Boosted-p24 antigen assay could be a cheaper alternative test to help diagnosis of perinatal HIV infection in infants. The test was very accurate when performed at 4-6 months.
