Publication: A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand.
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Accepted Date
2005-08-14
Issued Date
2005-08-14
Copyright Date
2005
Resource Type
Language
eng
ISSN
1475-2875 (electronic)
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Ohashi J, Naka I, Doi A, Patarapotikul J, Hananantachai H, Tangpukdee N, et al. A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. Malar J. 2005 Aug 14;4:38.
Suggested Citation
Ohashi, Jun, Naka, Izumi, Doi, Akihiro, Jintana Patarapotikul, จินตนา ภัทรโพธิกุล, Hathairad Hananantachai, Noppadon Tangpukdee, นพดล ตั้งภักดี, Sornchai Looareesuwan, ศรชัย หลูอารีย์สุวรรณ, Tokunaga, Katsushi A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand.. Ohashi J, Naka I, Doi A, Patarapotikul J, Hananantachai H, Tangpukdee N, et al. A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. Malar J. 2005 Aug 14;4:38.. doi:10.1186/1475-2875-4-38 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/807
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Title
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand.
Other Contributor(s)
Abstract
IL-1beta and IL-1RA levels are higher in the serum of cerebral
malaria patients than in patients with mild malaria. Recently, the level of IL1B
expression was reported to be influenced by a polymorphism in the promoter of
IL1, IL1B -31C>T.
METHODS: To examine whether polymorphisms in IL1B and IL1RA influence the
susceptibility to cerebral malaria, IL1B -31C>T, IL1B 3953C>T, and IL1RA variable
number of tandem repeat (VNTR) were analysed in 312 Thai patients with malaria
(109 cerebral malaria and 203 mild malaria patients).
RESULTS: In this population, IL1B -31C>T and IL1RA VNTR were detected, while IL1B
3953C>T (i.e., IL1B 3953T) was not observed in the polymorphism screening for 32
patients. Further analyses for IL1B -31C>T and IL1RA VNTR in 110 cerebral malaria
and 206 mild malaria patients showed no significant association of these
polymorphisms with cerebral malaria.
CONCLUSION: The present results suggest that IL1B -31C>T and IL1RA VNTR
polymorphisms do not play a crucial role in susceptibility or resistance to
cerebral malaria.