Publication: Curvularides A-E: Antifungal hybrid peptide-polyketides from the endophytic fungus Curvularia geniculata
Issued Date
2010-09-24
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ISSN
15213765
09476539
09476539
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2-s2.0-77956976795
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Mahidol University
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SCOPUS
Bibliographic Citation
Chemistry - A European Journal. Vol.16, No.36 (2010), 11178-11185
Suggested Citation
Porntep Chomcheon, Suthep Wiyakrutta, Thammarat Aree, Nongluksna Sriubolmas, Nattaya Ngamrojanavanich, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Curvularides A-E: Antifungal hybrid peptide-polyketides from the endophytic fungus Curvularia geniculata. Chemistry - A European Journal. Vol.16, No.36 (2010), 11178-11185. doi:10.1002/chem.201000652 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28922
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Title
Curvularides A-E: Antifungal hybrid peptide-polyketides from the endophytic fungus Curvularia geniculata
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Abstract
Five new hybrid peptide-polyketides, curvularides A-E (1-5), were isolated from the endophytic fungus Curvularia geniculata, which was obtained from the limbs of Catunaregam tomentosa. Structure elucidation for curvularides A-E (1-5) was accomplished by analysis of spectroscopic data, as well as by single-crystal X-ray crystallography. Curvularide B (2) exhibited antifungal activity against Candida albicans, and it also showed synergistic activity with a fluconazole drug. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA. Weinheim.