Publication: The effect of high dose of N-acetylcysteine in lupus nephritis: A case report and literature review
Issued Date
2010-08-01
Resource Type
ISSN
13652710
02694727
02694727
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2-s2.0-77954507692
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Clinical Pharmacy and Therapeutics. Vol.35, No.4 (2010), 483-485
Suggested Citation
K. Tewthanom, S. Janwitayanujit, K. Totemchockcyakarn, D. Panomvana Na Ayudhya The effect of high dose of N-acetylcysteine in lupus nephritis: A case report and literature review. Journal of Clinical Pharmacy and Therapeutics. Vol.35, No.4 (2010), 483-485. doi:10.1111/j.1365-2710.2009.01108.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29580
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Title
The effect of high dose of N-acetylcysteine in lupus nephritis: A case report and literature review
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Abstract
An imbalance of oxidative-antioxidant defence mechanism has been proposed in systemic lupus erythematosus patients. Co-administration of N-acetylcysteine (NAC) which has a strong antioxidant activity may produce a satisfactory therapeutic outcome when added to standard therapy. We report a case of a 46-year-old lupus nephritis patient who received 1800 mg of NAC orally. After NAC, this patient showed a higher glutathione level, and a normal level of malondialdehyde, a lipid peroxidation product. In addition, the urinary protein levels, the complete blood counts and physical examination of the affected organs showed improvement. However, a well-controlled trial is needed to confirm the value of high-dose NAC in lupus nephritis patients. © 2010 Blackwell Publishing Ltd.