Publication: Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase
| dc.contributor.author | Somchart Maenpuen | en_US |
| dc.contributor.author | Watcharee Amornwatcharapong | en_US |
| dc.contributor.author | Pasupat Krasatong | en_US |
| dc.contributor.author | Jeerus Sucharitakul | en_US |
| dc.contributor.author | Bruce A. Palfey | en_US |
| dc.contributor.author | Yongyuth Yuthavong | en_US |
| dc.contributor.author | Penchit Chitnumsub | en_US |
| dc.contributor.author | Ubolsree Leartsakulpanich | en_US |
| dc.contributor.author | Pimchai Chaiyen | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Burapha University | en_US |
| dc.contributor.other | Chulalongkorn University | en_US |
| dc.contributor.other | University of Michigan, Ann Arbor | en_US |
| dc.contributor.other | Thailand National Center for Genetic Engineering and Biotechnology | en_US |
| dc.date.accessioned | 2018-11-23T09:44:44Z | |
| dc.date.available | 2018-11-23T09:44:44Z | |
| dc.date.issued | 2015-03-27 | en_US |
| dc.description.abstract | © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: Plasmodium vivax serine hydroxymethyltransferase (PvSHMT) catalyzes formation of glycine from L-serine and tetrahydrofolate. Results: Results indicate that PvSHMT can bind to either substrate first. The rate constant of glycine formation is similar to kcat. Conclusion: PvSHMT reaction occurs via a random-order mechanism and glycine formation is the rate-limiting step. Significance: The data are useful for future investigation on inhibition of SHMT for antimalarial drug development. | en_US |
| dc.identifier.citation | Journal of Biological Chemistry. Vol.290, No.13 (2015), 8656-8665 | en_US |
| dc.identifier.doi | 10.1074/jbc.M114.612275 | en_US |
| dc.identifier.issn | 1083351X | en_US |
| dc.identifier.issn | 00219258 | en_US |
| dc.identifier.other | 2-s2.0-84925796253 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/35482 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84925796253&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.title | Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84925796253&origin=inward | en_US |