Publication: Relationship between plasma interleukin-12 (IL-12) and IL-18 levels and severe malarial anemia in an area of holoendemicity in western Kenya
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Issued Date
2003-06-01
Resource Type
ISSN
1071412X
Other identifier(s)
2-s2.0-0038633500
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Diagnostic Laboratory Immunology. Vol.10, No.3 (2003), 362-366
Suggested Citation
Sujittra Chaisavaneeyakorn, Caroline Othoro, Ya Ping Shi, Juliana Otieno, Sansanee C. Chaiyaroj, Altaf A. Lal, Venkatachalam Udhayakumar Relationship between plasma interleukin-12 (IL-12) and IL-18 levels and severe malarial anemia in an area of holoendemicity in western Kenya. Clinical and Diagnostic Laboratory Immunology. Vol.10, No.3 (2003), 362-366. doi:10.1128/CDLI.10.3.362-366.2003 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20724
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Title
Relationship between plasma interleukin-12 (IL-12) and IL-18 levels and severe malarial anemia in an area of holoendemicity in western Kenya
Abstract
In this study, we investigated whether levels of interleukin-12 (IL-12) and IL-18 in plasma are associated with severe malarial anemia outcomes in an area of holoendemicity in western Kenya. We compared plasma IL-12 and IL-18 levels in six groups of children grouped into the categories aparasitemic, asymptomatic, mild malaria, high-density uncomplicated malaria (UC), moderate malarial anemia (MMA), or severe malarial anemia (SMA). IL-12 levels were significantly reduced in children with SMA (P < 0.05) but not in other groups compared to children in the aparasitemic control group. IL-18, a cytokine known to be critical for the induction of gamma interferon along with IL-12, was produced more frequently (70%) in children with UC (P = 0.06) than in children in the aparasitemic control group (32%). However, in the SMA group the IL-18 response rate declined to 30%, which was similar to that in the aparasitemic control group, which showed a 32% response rate. This finding suggests that the IL-18 response may be impaired in children with SMA. In summary, the results from this study support the hypothesis that impairment of IL-12 and/or IL-18 response may contribute to the development of severe malarial anemia in areas of holoendemicity for malaria.