Obesity significantly affects the incidence of hepatic injury in patients with colorectal liver metastasis

Abstract

© 2018 Siriraj Medical Journal. Objective: Surgical resection is the mainstay treatment for colorectal liver metastasis. In unresectable cases, chemotherapy is used to transform the tumor into resectable lesions, with related concerns about toxicity to nontumoral liver parenchyma. Liver toxicity, including steatosis, steatohepatitis, and sinusoidal dilation, has been reported. However, these changes are difficult to histologically distinguish from non-alcoholic fatty liver disease, which is commonly found in populations and attributed mainly to metabolic syndrome. The aim of this study was to investigate the factors associated with liver injury in patients with colorectal liver metastasis. Methods: This retrospective study included the patients who underwent hepatic resection for colorectal liver metastasis at Siriraj Hospital during the eight-year period (2006 to 2013). Patient demographic data, clinical characteristics, and histologic changes related to liver injury were collected and analyzed. Ten factors were evaluated for association with liver injury in selected patients. Results: Ninety-two patients (50 men, 42 women) were included, with a mean age of 59.4 years (range: 48.5-70.3). Forty-four patients (47.8%) received preoperative chemotherapy (CMT). Incidence of liver injury was not significantly different between the CMT and non-CMT groups (65.9% vs. 62.5%; p=0.902). However, incidence of liver injury was significantly higher in obese patients than in non-obese patients (82.8% vs. 55.6%; p=0.022, odds ratio=3.95). Multivariate analysis showed that obesity (BMI > 25 kg/m2) was the only factor significantly associated with liver injury in patients with colorectal liver metastasis. Conclusion: Of the ten factors evaluated, obesity was the only factor found to be significantly associated with liver injury in patients with colorectal liver metastasis.