Publication:
Anti-inflammatory 12,20-Epoxypregnane and 11,12-seco-Pregnane Glycosides from the Stems of Hoya kerrii

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dc.contributor.authorChonticha Seekaen_US
dc.contributor.authorSamran Prabpaien_US
dc.contributor.authorPalangpon Kongsaereeen_US
dc.contributor.authorSupinya Tewtrakulen_US
dc.contributor.authorThitima Lhinhatrakoolen_US
dc.contributor.authorSomyote Sutthivaiyakiten_US
dc.contributor.otherRamkhamhaeng Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherPrince of Songkla Universityen_US
dc.contributor.otherRangsit Universityen_US
dc.date.accessioned2018-12-21T06:47:08Z
dc.date.accessioned2019-03-14T08:02:52Z
dc.date.available2018-12-21T06:47:08Z
dc.date.available2019-03-14T08:02:52Z
dc.date.issued2017-06-23en_US
dc.description.abstract© 2017 The American Chemical Society and American Society of Pharmacognosy. Five 12,20-epoxypregnane glycosides (1-3, 5, and 6) and two 11,12-seco-pregnane glycosides (4 and 7) with spirodilactone motifs, as well as spirodilactone cleavage products 8 and 9, were isolated from the stems of Hoya kerrii. The relative configurations of the three related skeletons were supported by ROESY experiments and X-ray crystallographic analyses. The isolates were evaluated for their anti-inflammatory activity based on the inhibition of NO production in RAW264.7 cells, and some showed IC50values ranging from 12.6 to 96.5 μM. The most potent compound, 9a, was also examined for its anti-inflammatory mechanism against mRNA expression and was found to down-regulate mRNA expression of iNOS and COX-2 in a dose-dependent manner.en_US
dc.identifier.citationJournal of Natural Products. Vol.80, No.6 (2017), 1714-1724en_US
dc.identifier.doi10.1021/acs.jnatprod.6b00730en_US
dc.identifier.issn15206025en_US
dc.identifier.issn01633864en_US
dc.identifier.other2-s2.0-85021128411en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/41867
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021128411&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.titleAnti-inflammatory 12,20-Epoxypregnane and 11,12-seco-Pregnane Glycosides from the Stems of Hoya kerriien_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021128411&origin=inwarden_US

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