Publication: Cytotoxicity of essential oil cordia verbenaceae against Leishmania brasiliensis and trypanosoma cruzi
Issued Date
2021-08-01
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ISSN
14203049
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2-s2.0-85111965582
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecules. Vol.26, No.15 (2021)
Suggested Citation
Pedro S. Pereira, Carlos Vinicius B. Oliveira, Ana J. Maia, Saulo R. Tintino, Cícera Datiane De M. Oliveira-Tintino, Maria C. Vega-Gomez, Miriam Rolón, Cathia Coronel, Antônia Eliene Duarte, Luiz M. Barros, Jeam Paul Kamdem, Abolghasem Siyadatpanah, Polrat Wilairatana, Henrique D.M. Coutinho Cytotoxicity of essential oil cordia verbenaceae against Leishmania brasiliensis and trypanosoma cruzi. Molecules. Vol.26, No.15 (2021). doi:10.3390/molecules26154485 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76084
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Title
Cytotoxicity of essential oil cordia verbenaceae against Leishmania brasiliensis and trypanosoma cruzi
Abstract
The species Cordia verbenacea DC (Boraginaceae), known as the whaling herb and camaradinha, is a perennial shrub species native to the Atlantic Forest. Its leaves are used in folk medicine as an anti-inflammatory, analgesic, antiulcerogenic and curative agent, in the form of teas or infusions for internal or topical use. The present study aimed to verify the cytotoxicity of the essential oil and the leishmanicidal and trypanocidal potential of C. verbenacea. The essential oil was characterized by GC-MS. The in vitro biological activity was determined by anti-Leishmania and anti-Trypanosoma assays. The cytotoxixity was determined using mammalian fibroblasts. The C. verbenacea species presented α-pinene (45.71%), β-caryophyllene (18.77%), tricyclo[2,2,1-(2.6)]heptane (12.56%) as their main compounds. The essential oil exhibited strong cytotoxicity at concentrations below 250 μg/mL (LC50 138.1 μg/mL) in mammalian fibroblasts. The potent anti-trypanosome and anti-promastigote activities occurred from the concentration of 62.5 μg/mL and was considered clinically relevant. The results also demonstrate that at low concentrations (<62.5 μg/mL), the essential oil of C. verbenacea managed to be lethal for these activities. This can be considered an indication of the power used in daily human consumption. Therefore, it can be concluded that the essential oil of C. verbenacea contains a compound with remarkable antiparasitic activities and requires further research.